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Table 2 Predictors of Dysbiosis Index and Alternative Dysbiosis Index (linear regression analyses)

From: Separating “good” from “bad” faecal dysbiosis – evidence from two cross-sectional studies

Independent predictors

Dependent: DI (all variables)

Dependent: DI (stepwise forward)

Dependent: ADI (all variables)

Dependent: ADI (stepwise forward)

B (95% CI)

p-value

pc

B (95%CI)

p-value

pc

B (95% CI)

p-value

pc

B (95%CI)

p-value

pc

Gender (female/male)

1.01

(0.17; 1.85)

0.19

0.275

   

−0.96

(−2.61; 0.70)

0.25

−0.137

   

Age (years)

−0.01

(−0.05; 0.02)

0.46

−0.088

   

0.05

(−0.02; 0.13)

0.15

0.172

0.07 (0.01; 0.13)

0.033

0.241

BMI (kg/m2)

−0.00

(−0.08; 0.08)

0.95

−0.007

   

−0.07

(−0.23; 0.09)

0.38

−0.105

   

Smoking (never/ previously /daily)

0.36

(−0.08; 0.80)

0.10

0.193

   

−0.67

(−1.53; 0.19)

0.12

−0.183

   

Coffee (cups/day)

−0.02

(−0.16 to 0.13)

0.79

−0.032

   

0.02

(−0.26; 0.31)

0.87

0.020

   

IBSSS (86)

0.00

(−0.002; 0.004)

0.47

0.086

   

−0.006

(−0.01; 0.00)

0.039

−0.244

−0.01

(−0.01; −0.00)

0.022

−0.258

Metformin

0.99

(0.22; 1.75)

0.012

0.295

1.11

(0.42; 1.80)

0.002

0.339

2.53

(1.04; 4.03)

0.001

0.374

2.32

(0.93; 3.71)

0.001

0.354

Water (unit a)

0.00

(−0.02; 0.02)

0.98

−0.002

   

−0.01

(−0.04; 0.03)

0.76

−0.037

   

Carb. bev. w/ sugar (unit a)

0.20

(−0,05; 0.45)

0.12

0.186

   

0.13

(−0.37; 0.63)

0.60

0.062

   

Total NNS (unit a)

0.035

(−0.00; 0.07)

0.054

0.228

0.04

(0.01; 0.07)

0.005

0.311

−0.08

(−0.15; −0.01)

0.024

−0.266

−0.10

(−0.16; −0.04)

0.001

−0.362

Starch (g/day)

−0.00

(−0.01; 0.00)

0.36

−0.109

   

−0.00

(−0.02; 0.01)

0.53

−0.076

   
  1. DI Dysbiosis Index, ADI Alternative Dysbiosis Index, IBSSS Irritable Bowel Severity Scoring System, NNS Non-Nutritive Sweeteners, pc partial correlation, Carb. bev: Carbonated beverages. aOne unit is 100 ml beverages with NNS or 2 tablets NNS for coffee/tea
  2. Gender and BMI and all variables significantly associated with either DI of ADI in the univariate analyses (age, smoking habits, coffee, IBSSS, Metformin, total NNS, starch) were included as predictors of DI and ADI in the regression analyses. The reasons for exclusion of diabetes and some nutrients are explained in the text. All the variables were included in the first step, and then stepwise forward regression analyses were performed
  3. Italicized p-values are statistically significant