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Table 1 Clinical and pathological characteristics of 405 primary breast tumors evaluated by microarray analysis

From: Effect of obesity on molecular characteristics of invasive breast tumors: gene expression analysis in a large cohort of female patients

 

Normal-weight (n = 131)

Overweight (n = 132)

Obese (n = 142)

P-value

Age

   

0.031

 <40 years

0.15

0.11

0.06

 

 40–49 years

0.27

0.20

0.22

 

 ≥50 years

0.58

0.69

0.72

 

Ethnicity

   

0.031

 African American

0.17

0.19

0.32

 

 Asian

0.04

0.02

0.01

 

 Hispanic

0.02

0.02

0.01

 

 Other

0.01

0.02

0.01

 

 Non-Hispanic White

0.76

0.75

0.65

 

Tumor Size

   

0.130

 T1

0.59

0.56

0.50

 

 T2

0.35

0.34

0.45

 

 T3

0.06

0.10

0.05

 

Tumor Grade

   

0.216

 Well (Grade 1)

0.23

0.21

0.19

 

 Moderate (Grade 2)

0.42

0.35

0.32

 

 Poor (Grade 3)

0.35

0.44

0.49

 

Intrinsic Subtype

   

0.560

 Luminal A

0.52

0.48

0.54

 

 Luminal B

0.13

0.08

0.11

 

 HER2-enriched

0.11

0.16

0.08

 

 Basal-like

0.23

0.27

0.24

 

 Normal-like

0.01

0.01

0.03

 

Lymph Node Status

   

0.447

 Positive

0.36

0.40

0.44

 

 Negative

0.64

0.60

0.56

 

TNM Stage

   

0.144

 Stage I

0.45

0.40

0.31

 

 Stage II

0.41

0.42

0.48

 

 Stage III

0.12

0.12

0.18

 

 Stage IV

0.02

0.06

0.03

 

Statusa

   

0.929

 Died of disease

0.08

0.07

0.07

 

 Died other causes

0.02

0.03

0.02

 

 Alive with disease

0.05

0.05

0.03

 

 Alive, disease-free

0.85

0.85

0.88

 
  1. aPatient status included died of disease if that patients died of metastatic breast cancer, and died other causes if a patient died from other health conditions. Patients Alive with disease were diagnosed with or have progressed to stage IV breast cancer while those Alive, disease-free have had no additional breast cancer-events since diagnosis and treatment of the original primary breast tumor