Sample | Recovery expressed as % of the applied dose | |
---|---|---|
Group A | Group B | |
Control (untreated) | Formoline l112 | |
Urine | ||
-48–24 h | 0.00 ± 0.01 | 0.00 ± 0.00 |
-24–0 h | 0.01 ± 0.00 | 0.00 ± 0.00 |
0–24 h | 0.79 ± 0.05 | 0.46 ± 0.28 |
24–48 h | 0.28 ± 0.10 | 0.54 ± 0.14 |
48–72 h | 0.09 ± 0.08 | 0.25 ± 0.17 |
72–96 h | 0.08 ± 0.05 | 0.10 ± 0.04 |
96–120 h | 0.05 ± 0.03 | 0.07 ± 0.04 |
120–144 h | 0.03 ± 0.00 | 0.05 ± 0.02 |
Total | 1.33 ± 0.20 | 1.46 ± 0.17 |
Faeces | ||
-48–24 h | 0.00 ± 0.00 | 0.00 ± 0.00 |
-24–0 h | 0.00 ± 0.00 | 0.00 ± 0.00 |
0–24 h | 0.02 ± 0.02 | 0.06 ± 0.06 |
24–48 h | 2.22 ± 2.05 | 1.45 ± 1.94 |
48–72 h | 3.21 ± 2.93 | 3.02 ± 1.43 |
72–96 h | 0.85 ± 0.83 | 2.17 ± 2.21 |
96–120 h | 0.15 ± 0.13 | 0.32 ± 0.16 |
120–144 h | 0.06 ± 0.03 | 0.13 ± 0.09 |
Total | 6.51 ± 2.88 | 7.15 ± 2.87 |
Cagewash | 0.07 ± 0.07 | 0.10 ± 0.07 |
Total excreted (sum urine, faeces, cagewash) | 7.90 ± 3.13 | 8.72 ± 2.75 |
Liver at sacrifice (144 h post-dose) | 0.37 ± 0.07 | 0.37 ± 0.03 |
GI-tract contents at sacrifice (144 h post-dose) | 0.08 ± 0.04 | 0.13 ± 0.06 |