A single oral dose of a polyglucosamine influences the bioavailability of [9-14C]-Oleic acid in adult female Göttingen minipigs

Table 2 Pharmacokinetic parameters (non-compartmental analysis) of [9-¹⁴C]-oleic acid and/or its metabolites in plasma and blood of Göttingen minipigs after a single oral dose of [9-¹⁴C]-Oleic to untreated minipigs (group A) and minipigs that were pre-treated with 2 tablets of 500 mg formoline L112 (group B)

Group	A	B	%^a	A	B	%^a
	Plasma			Blood
Pharmacokinetic parameters
T_max (h)	4 ± 3	16 ± 9*	-	4 ± 3	14 ± 11	-
C_max (μg/g)	14.1 ± 3.6	3.3 ± 1.2**	23.4	8.5 ± 2.2	2.1 ± 0.8**	24.7
AUC_(0-12h) (h* μg/g)	65.6 ± 6.0	21.6 ± 14.0**	32.9	40.0 ± 4.8	13.3 ± 9.1**	33.3
AUC_(0-24h) (h* μg/g)	98.4 ± 17.2	49.9 ± 20.8**	50.7	61.7 ± 13.1	29.8 ± 12.9**	48.3
AUC_(0-48h) (h* μg/g)	136 ± 28	91.0 ± 23.2*	66.9	88.3 ± 19.0	56.9 ± 13.1*	64.4
AUC_(0-60h) (h* μg/g)	148 ± 31	105 ± 25*	70.9	97.2 ± 20.6	67.3 ± 13.8*	69.2
AUC_(0-72h) (h* μg/g)	157 ± 32	116 ± 26	73.9	105 ± 22	76.4 ± 14.2*	72.8
AUC_all(0-144h) (h* μg/g)	190 ± 38	158 ± 32	83.2	139 ± 25	118 ± 16	84.9
Vz (g/kg)	7008 ± 2962	5629 ± 1946	-	8860 ± 1848	9515 ± 1647	-
Cl (g/h/kg)	40.7 ± 5.5	49.8 ± 8.3	-	48.4 ± 7.9	47.6 ± 7.3	-
MRTlast (h)	35.9 ± 1.8	50.2 ± 5.1**	-	43.6 ± 3.1	58.4 ± 5.7**	-

^aPercentage of radioactivity remaining in plasma or blood following pre-treatment with formoline L112 compared to the untreated control group
* P ≤ 0.05, ** P ≤ 0.01

ISSN: 2052-9538