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Table 3 Odds ratios (OR) for short LTLa by subject characteristics and markers of inflammation

From: Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus

Characteristic

N

Unadjusted OR (95 % CI)

Age & gender adjusted OR (95 % CI)

Age, gender, smoking & obesity adjusted OR (95 % CI)

Age (per year)

295

1.05 (1.03,1.07)

1.05 (1.03,1.08)

1.04 (1.02,1.07)

Gender (Females vs. males)

295

0.46 (0.23,0.92)

0.43 (0.21,0.87)

0.37 (0.18,0.78)

BMI (per kg/m2)

290

0.91 (0.85,0.97)

0.93 (0.87,1.00)

0.96 (0.86,1.07)

Waist circumference (per inch)

294

0.96(0.91,1.02)

0.94(0.88,1.00)

0.94 (0.88,1.00)

Waist-hip ratio (per unit)

294

1.11(0.77,1.60)

0.72(0.45,1.16)

0.92 (0.49,1.74)

Cigarette use (Ever vs. never)

295

1.01 (1.00,1.03)

1.01 (0.99,1.03)

0.99 (0.96,1.03)

Pack-years continuous (per pack-year)

295

1.01 (1.00,1.02)

1.01 (1.00,1.02)

1.01 (1.00,1.02)

Pack-years Tertiles

   

-

Non-smokers

 

REF

REF

REF

T1 (0.05-)

 

0.58 (0.28,1.20)

0.64 (0.30,1.35)

0.64 (0.30,1.37)

T2 (14-)

 

0.91 (0.47,1.76)

0.79 (0.40,1.57)

0.84 (0.42,1.70)

T3 (36-)

 

1.58 (0.83,3.01)

1.30 (0.66,2.56)

1.40 (0.70,2.77)

p-trendb

 

0.04**

0.27

0.20

Leptin (ng/ml)

226

0.98 (0.95,1.01)

1.00 (0.97,1.04)

1.05 (1.01,1.12)

Total Adiponectin (mcg/ml)

226

1.08 (0.97,1.20)

1.00 (0.88,1.15)

0.98 (0.85,1.12)

HMW Adiponectin (mcg/ml)

226

1.10 (0.92,1.30)

0.98 (0.79,1.21)

0.92 (0.74,1.15)

Glucose (mg/dL)

226

0.99 (0.98,1.01)

0.99 (0.97,1.01)

0.99 (0.97,1.01)

Insulin (uU/ml)

226

1.00 (0.95,1.04)

1.00 (0.95,1.05)

1.02 (0.97,1.07)

HOMA score

226

0.95 (0.82,1.09)

0.95 (0.81,1.12)

1.01 (0.86,1.18)

CRP continuous (mg/L)

222

0.98 (0.87,1.11)

0.95 (0.82,1.09)

0.98 (0.84,1.13)

CRP Tertiles

    

T1 (0.1-)

 

REF

REF

REF

T2 (1.1-)

 

1.36 (0.67,2.74)

1.40 (0.66,2.96)

1.69 (0.78,3.68)

T3 (2.9-)

 

0.91 (0.45,1.85)

0.81 (0.37,1.78)

1.04 (0.45,2.40)

p-trendb

 

0.74

0.44

0.74

IL-6 continuous (pg/ml)

234

1.06 (0.95,1.17)

1.02 (0.90,1.15)

1.04 (0.92,1.18)

IL-6 Tertiles

    

T1 (0.4-)

 

REF

REF

REF

T2 (1.5-)

 

1.45 (0.74,2.86)

1.21 (0.58,2.50)

1.25 (0.59,2.62)

T3 (2.6-)

 

1.25 (0.63-2.47)

1.07 (0.50,2.31)

1.22 (0.55,2.71)

p-trendb

 

0.32

0.77

0.51

sTNF-RI continuous (ng/ml)

234

3.30 (1.75,6.23)

2.02 (1.02,3.99)

2.30 (1.11,4.78)

sTNF-RI Tertiles

    

T1 (0.3-)

 

REF

REF

REF

T2 (1.2-)

 

1.14 (0.56,2.33)

0.90 (0.42,1.91)

1.00 (0.46,2.15)

T3 (1.5-)

 

3.25 (1.64,6.43)

1.81 (0.85,3.84)

2.19 (1.00,4.85)

p-trendb

 

<0.001**

0.04**

0.02 **

sTNF-RII continuous (ng/ml)

234

1.30 (1.07,1.58)

1.08 (0.86,1.35)

1.06 (0.84,1.33)

sTNF-RII Tertiles

    

T1 (2.1-)

 

REF

REF

REF

T2 (4.9-)

 

0.90 (0.44,1.82)

0.64 (0.30,1.37)

0.68 (0.32,1.47)

T3 (6.0-)

 

2.52 (1.29,4.90)

1.42 (0.66,3.04)

1.45 (0.67,3.15)

p-trendb

 

0.01**

0.50

0.62

F2-isoprostanes continuous (pg/ml)

224

1.00 (0.99,1.01)

1.00 (1.00,1.01)

1.01 (1.00,1.02)

F2-isoprostane Tertiles

    

T1 (14-)

 

REF

REF

REF

T2 (48-)

 

0.62 (0.31,1.25)

0.67 (0.32,1.41)

0.72 (0.34,1.52)

T3 (67-)

 

0.93 (0.48,1.83)

1.28 (0.60,2.71)

1.55 (0.71,3.39)

p-trendb

 

0.88

0.31

0.18

  1. LTL leukocyte telomere length, BMI body mass index, CRP c-reactive protein, IL-6 interleukin-6, sTNF-RI & RII Soluble tumor necrosis factor receptor I & II, CI confidence interval
  2. £ - Adjusted for cigarette pack-years smoked at baseline, € - Adjusted for waist circumference at baseline, ₤ = Adjusted only for gender, € = Adjusted only for age
  3. ** p-value significant at 0.05 level
  4. aShort LTL defined as lowest tertile (T/S ratio < 0.735)
  5. bTest for trend based on the likelihood-ratio test associated with addition of the variable under consideration in its continuous form