Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus

Table 2 Biomarker concentrations and their linear associations with leukocyte telomere length^c

Biomarkers		Leukocyte telomere length tertile^b			Pearson’s correlation coefficient^a	Linear regression
Biomarkers	n	Short (n = 76)	Middle (n = 80)	Long (n = 78)	Pearson’s correlation coefficient^a	Age & gender adjusted beta (95 % CI)	P-value
Leptin (ng/ml)	287	7.8 (10.3)	9.5 (12.3)	10.1 (10.3)	−0.01	−0.0001 (−0.002, 0.002)	0.90
Total adiponectin (mcg/ml)	226	5.2 (2.8)	5.4 (2.4)	4.4 (2.5)	−0.01	−0.001 (−0.007, 0.006)	0.88
HMW adiponectin (mcg/ml)	226	1.9 (1.7)	2.0 (1.6)	1.8 (1.6)	0.01	0.001 (−0.010, 0.011)	0.90
Glucose (mg/dL)	226	91.0 (14.6)	91.5 (28.4)	93.0 (30.3)	0.04	0.0002 (−0.0004, 0.0008)	0.52
Insulin (uU/ml)	226	7.2 (5.2)	6.4 (7.7)	6.9 (5.4)	−0.001	−0.0001 (−0.0024, 0.0024)	0.99
HOMA score	226	1.6 (1.3)	1.5 (3.3)	1.6 (1.7)	0.01	0.0003 (−0.006, 0.007)	0.93
C-reactive protein (mg/L)	222	2.1 (2.3)	1.8 (2.5)	2.3 (2.1)	−0.04	−0.002 (−0.009, 0.005)	0.57
Interleukin-6 (pg/ml)	234	2.1 (2.7)	2.0 (2.9)	1.7 (1.6)	−0.10	−0.005 (−0.011, 0.001)	0.11
sTNF-RI (ng/ml)	234	1.5 (0.5)	1.3 (0.4)	1.3 (0.5)	−0.06	−0.016 (−0.050, 0.020)	0.36
sTNF-RII (ng/ml)	234	5.6 (1.6)	5.3 (1.5)	5.0 (1.1)	−0.003	−0.0003 (−0.012, 0.011)	0.96
F2-isoprostanes (pg/ml)	224	54.0 (34.2)	57.5 (26.5)	54.0 (38.3)	−0.04	−0.0002 (−0.0006, 0.0003)	0.53

Leukocyte telomere length tertile: Short < 0.735, Middle 0.735-0.846, Long ≥ 0.847
sTNF-RI & RII soluble tumor necrosis factor receptor I & II, HMW high molecular weight, HOMA score homeostatic model assessment score
^aAdjusted for age & gender
^bMedian (standard deviation)
^cThe correlation and regression values are based on leukocyte telomere length as a continuous variable

ISSN: 2052-9538