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Table 2 Delta changes in baseline parameters after 52 weeks according to randomization group

From: Cardiac natriuretic peptides in plasma increase after dietary induced weight loss in obesity

 

Intervention (n = 28)

Control (n =24)

Mean difference (95% CI)

P value (differences between groups)

∆ Weight (kg)

−14.2 ± 1.6a

−6.1 ± 1.2a

−8.8 (−12.3, −3.9)

<0.0001

∆ BMI (kg/m2)

−5.4 ± 0.6a

−2.2 ± 0.3a

−3.2 (−4.8, −1.6)

<0.0001

∆ Fat mass (kg)

−11.5 ± 1.5a

−4.4 ± 1.2a

−7.0 (−11, −3.1)

0.001

∆ Fat-free mass (kg)

−0.9 ± 0.5c

−0.5 ± 4.0c

−0.4 (−1.7, 0.9)

0.54

∆ NT-proBNP (pg/ml)

42 ± 9a

4 ± 7c

−38 (−61, −14)

0.002

∆ MR-proANP (pmol/l)

15 ± 4b

5 ± 5c

−11 (−22, 1)

0.071

∆ MR-proADM (pmol/l)

−56 ± 15b

−19 ± 35b

37 (−37, 111)

0.32

∆ Plasma glucose (mmol/l)

−0.6 ± 0.3a

−0.4 ± 0.3a

−0.2 (−0.4, 0.2)

0.31

∆ CRP (mg/l)

−2.0 ± 0.9b

−0.9 ± 1.3c

−1.2 (−4.3, 2.0)

0.46

∆ Cholesterol (mmol/l)

−0.2 ± 0.2c

0.03 ± 0.2c

−0.3 (−0.6, 0.3)

0.50

∆ LDL cholesterol (mmol/l)

−0.2 ± 0.1c

−0.2 ± 0.1c

0.1 (−0.3, 0.5)

0.70

∆ HDL cholesterol (mmol/l)

0.1 ± 0.1b

0.2 ± 0.1b

0.1 (−0.1, 0.3)

0.22

∆ Triglycerides (mmol/l)

−0.5 ± 0.2b

0.05 ± 0.1c

−0.5 (−1.1, 0.1)

0.083

∆ s-creatinine (μmol/l)

−3.0 ± 1.0b

−5.0 ± 2.0b

1.8 (−3, 7)

0.45

∆ eGFR (ml/min)

6.1 ± 3.0d

7.0 ± 3.0b

1.0 (−8, 10)

0.82

  1. Data are expressed as mean ± SEM, if not stated otherwise. NS, Not significant.
  2. aP < 0.001, compared to baseline.
  3. bP < 0.05, compared to baseline.
  4. cno significant difference from baseline.
  5. dP = 0.051.