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Table 2 Effect of hormones on BAT and possible therapeutic options

From: Brown adipose tissue: endocrine determinants of function and therapeutic manipulation as a novel treatment strategy for obesity

Hormone

Influence on BAT

Probable BAT therapeutic suggestions

Epinephrine

+ve

Selective human β3 receptor agonists

T3

+ve

TR β selective agonists- GC-40, KB-41

Testosterone

-ve

To be determined

Estradiol

+/− (? dual effect)

Selective estrogen receptor modulators (SERM)

Progesterone

+ve

To be determined

DHEA

+ve

To be determined

IGF-1

Probably + ve

Recombinant human IGF-1 or truncated IGF-1

GH

+ve at higher dose

To be determined

Insulin

Unclear

To be determined

Cortisol

-ve

To be determined

Prolactin

-ve

Bromocriptine, pure prolactin receptor antagonists eg., ∆1–9-G129R- hPrl (∆1–9)

Aldosterone

-ve

Eplerenone, Spironolactone

Endocannabinoids

-ve

Peripheral CB1 antagonists